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KMID : 1161420170200010011
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Journal of Medicinal Food
2017 Volume.20 No. 1 p.11 ~ p.18
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Gynostemma pentaphyllum Ethanolic Extract Protects Against Memory Deficits in an MPTP-Lesioned Mouse Model of Parkinson's Disease Treated with L-DOPA
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Kim Kyung-Sook
Zhao Ting Ting
Shin Keon-Sung
Park Hyun-Jin
Cho Yoon-Jeong
Lee Kyung-Eun
Kim Seung-Hwan
Lee Myung-Koo
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Abstract
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This study investigated the effects of ethanol extract from Gynostemma pentaphyllum (GP-EX) on memory deficits in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned mouse model of Parkinson's disease (PD) (MPTP-lesioned mice). MPTP (30?mg/kg/day, 5 days)-lesioned mice showed deficits of habit learning memory and spatial memory, which were further aggravated by treatment with L-3,4-dihydroxyphenylalanine (L-DOPA) (25?mg/kg, 21 days). However, treatment with GP-EX (50?mg/kg, 21 days) ameliorated memory deficits in MPTP-lesioned mice treated with L-DOPA (25?mg/kg): GP-EX prevented the decreases in retention latency time in the passive avoidance test and tyrosine hydroxylase-immunopositive cells and dopamine levels in the nigrostriatum. GP-EX also reduced increases in retention transfer latency time of the elevated plus-maze test and expression of N-methyl-D-aspartate (NMDA) receptor and improved decreases in phosphorylation of extracellular signal-regulated kinase (ERK1/2) and cyclic AMP-response element binding protein (CREB) in the hippocampus in the same models. By contrast, L-DOPA treatment (10?mg/kg, 21 days) ameliorated memory deficits in MPTP-lesioned mice, which were further improved by GP-EX treatment. These results suggest that GP-EX ameliorates habit learning memory deficits by activating dopaminergic neurons and spatial memory deficits by modulating NMDA receptor-ERK1/2-CREB system in MPTP-lesioned mice treated with L-DOPA. GP-EX may serve as an adjuvant phytonutrient for memory deficits in PD.
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KEYWORD
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Gynostemma pentaphyllum, L-DOPA, memory deficits, MPTP-lesioned mouse, Parkinson's disease
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